Matthew James Bellamy was born in Cambridge, England. His father, George Bellamy, was the rhythm guitarist of the 1960s pop group the Tornados, and his mother, Marilyn, was from Belfast.

Bellamy began playing the piano at age six and the guitar at age eleven.

Bellamy gave his first musical performance at age 12, playing piano in front of his school at Teignmouth Community School.

Bellamy, along with Dominic Howard and Chris Wolstenholme, formed the band Muse after winning their school's "Battle of the Bands" competition while using the name Rocket Baby Dolls. This win led them to take the band more seriously and change their name to Muse.

Muse released their debut album, Showbiz, showcasing Bellamy's falsetto and a melancholic alternative rock style.

Muse's second album, Origin of Symmetry, expanded their sound, incorporating wider instrumentation and romantic classical influences, earning them a reputation for energetic live performances.

Muse released Absolution, which featured further classical influence and became the first of seven consecutive UK number-one albums for the band.

Total Guitar readers voted Bellamy the 29th-greatest guitarist and his "Plug in Baby" riff the 13th-greatest riff.

Kerrang! named Bellamy the 28th-sexiest person in rock.

Muse released Black Holes and Revelations, which incorporated electronic and pop elements and brought the band wider international success.

Bellamy won the Sexiest Male Award at the NME Awards.

Muse became the first band to sell out the newly built Wembley Stadium in London, performing on June 16 and 17.

Gigwise named Bellamy the 19th-greatest guitarist ever.

The University of Plymouth awarded the members of Muse an honorary doctorate degree for their work in music.

Bellamy co-wrote the end credits for the film The International.

Muse released The Resistance, which explored themes of government oppression and civil uprising and won a Grammy Award for Best Rock Album.

Bellamy was named the third-best guitarist of the last 30 years in a BBC Radio 6 survey.

Bellamy is credited in the Guinness Book of World Records as holding the world record for most guitars smashed on a tour, with 140 guitars smashed during the Absolution Tour.

In the January edition of Total Guitar, Bellamy was named "Guitarist of the Decade" and was proclaimed to be "the Hendrix of his generation".

MusicRadar readers voted Bellamy the 9th greatest lead singer of all time.

Bellamy and Kate Hudson became engaged.

Bellamy and Kate Hudson's son, Bingham, was born.

Bellamy won the "Hero of the Year" award at the NME Awards.

Muse received the Ivor Novello Award for International Achievement from the British Academy of Songwriters, Composers and Authors.

Muse released The 2nd Law, which explored themes of government oppression and civil uprising and cemented the band as one of the world's major stadium acts.

Bellamy contributed to the second album by the New Zealand artist Kimbra, The Golden Echo.

Bellamy and Hudson ended their engagement.

Muse released Drones, a concept album about drone warfare, which won a Grammy Award for Best Rock Album.

Bellamy began dating Elle Evans.

Bellamy cofounded the Jaded Hearts Club, a supergroup to perform covers of Beatles songs.

Bellamy bought the former home of tennis player Pete Sampras in Brentwood, Los Angeles.

Bellamy and Elle Evans announced their engagement.

Muse released Simulation Theory, featuring a retro 1980s style.

Bellamy composed his first solo release, "Pray", for For the Throne, a compilation album of music inspired by the TV series Game of Thrones.

Bellamy purchased a majority stake in Manson Guitar Works.

Bellamy and Elle Evans married.

The Jaded Hearts Club released their album, You've Always Been Here, produced by Bellamy.

Bellamy purchased the Fender Telecaster used by Buckley for Grace.

Bellamy released his second solo composition, "Tomorrow's World", inspired by life under lockdown during the COVID-19 pandemic.

Bellamy and Elle Evans' daughter, Lovella, was born.

Bellamy released a compilation of his solo work, Cryosleep, for Record Store Day.

Muse released their ninth album, Will of The People.

Bellamy wrote the score for a 2024 audiobook adaptation of the novel Nineteen Eighty-Four for Audible, with British composer Ilan Eshkeri.

Evans gave birth to their second child, George.